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News | Dec. 3, 2020

Historical bias overlooks genes related to COVID-19

By Thomas Stoeger and Luís A Nunes Amaral

Why are some genes studied more than others? Minerva-funded researchers and colleagues from Northwestern University find large number of genes that have been implicated in SARS-CoV-2 infection by four genome-wide studies remain unstudied.

It is known that research into human genes is heavily skewed towards genes that have been widely studied for decades, including many genes that were being studied before the productive phase of the Human Genome Project. This means that the genes most frequently investigated by the research community tend to be only marginally more important to human physiology and disease than a random selection of genes. Based on an analysis of 10,395 research publications about SARS-CoV-2 that mention at least one human gene, we report here that the COVID-19 literature up to mid-October 2020 follows a similar pattern. This means that a large number of host genes that have been implicated in SARS-CoV-2 infection by four genome-wide studies remain unstudied. While quantifying the consequences of this neglect is not possible, they could be significant.

Link:  https://elifesciences.org/articles/61981